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HYALURONIDASE

Experience exceptional plastic surgery with Dr. J. J. Wendel in Nashville, Tennessee.

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HYALURONIDASE

By Paige Hastings

Experienced and Board Certified Advanced Nurse Practitioners

Were you seen by an inexperienced injector who gave you too much filler? Do you have lumpy areas of filler that you would like to smooth out? We can help. The advanced, highly skilled providers at Dr. J. J. Wendel Plastic Surgery offer expert hyaluronidase injections to fine tune your results or correct over-injection.

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HYALURONIDASE

Are you dissatisfied with the results of your injectable filler such as Belotero, Hylaform, Juvederm, or Restylane? Do you have lumps or too much on one side or the other? The answer is yes. These fillers can be taken out.

As long as the filler is hyaluronic acid-based and not a permanent one, a naturally occurring enzyme called hyaluronidase can be used to dissolve the unwanted filler.

The injection works quickly, usually within 24 hours, and typically dissolves all of the filler. It is very difficult, however, to only dissolve part of the filler leaving some behind. After the filler dissolves, your body absorbs and removes it.

There are two popular types of hyaluronidase on the market: Hylenex and Vitrase.

HYALENEX®

Hylenex is the first and only recombinant hyaluronidase that is FDA approved to increase the dispersion and absorption of other drugs, particularly hyaluronic acid-based fillers. It is human-based.

VITRASE

Vitrase is a hylauronidase enzyme derived from Sheep and is also FDA-approved. It is the only hyaluronidase preparation approved in concentrations > 150 USP units/mL.

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FAQ's
What is Hyaluronidase?
Hyaluronidase is an enzyme that breaks down hyaluronic acid-based fillers, used to reverse or correct previous filler treatments.
When is it used?
It is used to correct overfilling, asymmetry, lumps, or migration from prior filler treatments.
How fast does it work?
Effects can be seen within minutes to a few days after the injection.
Is it safe?
Yes, it is a safe and commonly used procedure when performed by trained professionals.
Are there side effects?
Possible side effects include minor swelling, bruising, or tenderness at the injection site.
Can I get fillers again after dissolving?
Yes, typically you can receive new filler treatments after about 1–2 weeks once the area has settled.
Will it affect my natural tissues?
Hyaluronidase targets hyaluronic acid and does not damage your natural collagen or tissue.
Is allergy testing necessary?
Sometimes a patch test is done to check for allergic reactions, though it's rare.
How many sessions are required?
Often only one session is needed, but complex cases may require more.
Is the procedure painful?
It is generally well tolerated, especially with numbing cream or local anesthesia.
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